Taking clomipramine with other drugs that make you sleepy or slow your breathing can increase these effects. Ask your doctor before taking clomipramine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
Before taking clomipramine, tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine (Paxil), sertraline (Zoloft), trazodone, or vilazodone (Viibryd).
Many drugs can interact with clomipramine. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with clomipramine, especially:
- St. John's wort;
- anti-malaria medication;
- a barbiturate such as phenobarbital or secobarbital;
- bladder or urinary medicines such as darifenacin, fesoterodine, oxybutynin, tolterodine, solifenacin;
- bronchodilators such as ipratropium or tiotropium;
- cold or allergy medicine, stimulants, or ADHD medication;
- cough medicine that contains dextromethorphan;
- heart or blood pressure medication;
- medication to treat an infection caused by fungus;
- medication to treat HIV or AIDS;
- medication to treat excess stomach acid, stomach ulcer, motion sickness, or irritable bowel disease;
- medication for Parkinson's disease, such as ropinirole (Requip);
- medicine to treat depression or mental illness; or
- thyroid medication.
This list is not complete and many other drugs can interact with clomipramine.